Immunotherapy And Glioblastoma Multiforme
GBM is the most common primary brain tumor. As per the World Health Organization
(WHO), GBM is classified as grade IV glioma. GBM is invasive and penetrates the
adjoining brain tissue. Incidence is higher in case of men and […]
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IMMUNOTHERAPY AND HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is considered the most common primary cancer of
the liver. HCC accounts for 90% of all liver cancers.HCC is the fifth common
cause of cancer in men and seventh in women worldwide. It is the second most
[…]
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Immunotherapy And Gastroenteropancreatic Neuroendocrine Tumor
Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) originates from the hormone
producing cells of the gut along with rectum and pancreas.GEP-NET represents 75%
of all neuroendocrine tumors (NETs). […]
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IMMUNOTHERAPY AND MALIGNANT PLEURAL MESOTHELIOMA
Malignant pleural mesothelioma is an aggressive type of cancer in which cancerous
cells are found in the lining of the abdomen or chest that occurs due to
asbestos exposure in the mesothelium. According to the National Cancer
Institute's […]
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IMMUNOTHERAPY AND PANCREATIC CANCER
Integrative Gastroenterology and Hepatology Immunotherapy and Pancreatic Cancer
Allen T* , Shoja G and Court NB Global Allied Pharmaceuticals, Center for
Excellence in Research and Development, USA * Correspondence: Timothy Allen,
Global Allied Pharmaceuticals, Center for Excellence in Research and […]
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Immunotherapy and Meningioma Timothy Allen*, Ariel Sheikkhon, Shoja E Razavi,
Naveed Basha Court Global Allied Pharmaceuticals, Center for Excellence in
Research and Development, USA. timallenmed69@gmail.com *Corresponding Author:
Timothy Allen, Global Allied Pharmaceuticals, Center for Excellence in Research
and Development, 160 […]
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Immunotherapy And Penis Cancer
Abstract Penis cancer, a cancerous disease in which malignant cells appear in the
tissues of the penis. It occurs in the uncircumcised older men. It is recognized
by at least two independent carcinogenic routes: virus and non-virus induced.
The penis […]
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Download Abstract Diffuse large B-cell lymphoma (DLBCL) in the most common type
of non-Hodgkin's lymphoma (NHL) in developed world, so far and approximately
60,000 new non-Hodgkin lymphoma (NHL) cases and 20,000 deaths have been
estimated in the United States for […]
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Download Abstract Diffuse large B cell lymphoma (DLBCL) in the most common type
of non-Hodgkin's lymphoma (NHL) in developed world, so far and approximately
60,000 new non-Hodgkin lymphoma (NHL) cases and 20,000 deaths have been
estimated in the United States […]
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Abstract Download Worldwide incidence of malignant melanoma has been constantly
increasing during the last years. Surgical excision is effective when primary
tumors are thin with thickness of less than 1milli meter and there is no
evidence of metastases. At later […]
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Gastrointestinal Events Associated With Ipilimumab And Combination Therapies
Download Gastrointestinal Events Associated with Ipilimumab, Pazopanib, Anti PD1-
Antibody and Their Management: Single and Combination Therapies Timothy Allen,
MD, Ph.D1*, Giridhar M.N.V, MD,MBA1*, Ghazaleh Shoja E Razavi MD2 1Global Allied
Pharmaceutical, Center for Excellence in Research & Development, USA. […]
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PROTEASOME INHIBITION IN LYMPHOPROLIFERATIVE DISORDER.
Abstract Download Proteasomes are multi-subunit protein complexes, which present
numerous targets for therapeutic interference. The most commonly used proteasome
is 26S proteasome, which contains one 20S proteolytic core subunit and two 19S
regulatory cap subunits. There are three different types […]
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Toxicities Associated With Antibody Drug Conjugates
Abstract Download Conventional chemotherapeutic agents, in the treatment of
several cancers, lack specificity, resulting in toxicities to normal tissues and
poor therapeutic index. Antibody-based immunoconjugates are specifically
targeted monoclonal antibodies that deliver the cytotoxic agent to the target
cell. When […]
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Mechanisms Of Drug Resistance In Glioblastoma Multiforme.
Abstract Download Glioblastoma multiforme (GBM) is a group of low-grade as well
as high-grade brain tumors that originate from the glia;neuroglial cells and are
the most common and crucial brain tumor, specially in adults. The main causes
are deemed to […]
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Abstract Download Blockade of various immune targets such as cytotoxic
T-lymphocyte antigen-4 and Programmed cell death leads to immune-mediated tumor
regression and immune-related adverse events, predominantly gastrointestinal
events including diarrhea and colitis. The current review is done to understand
the […]
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A Review Of Newer Technologies In Development Of Nanomedicines For Cancers.
Abstract Download Cancer is the leading cause of morbidity and mortality
worldwide. Advances in nanotechnology have contributed to the development of
nanoparticles used for medical applications and optimized therapy. Due to unique
features of nanoparticles, like a large surface area, […]
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Safety And Efficacy Of Peptide Based Vaccines.
Download Abstract A vaccine is a biological preparation which produces immunity
from diseases or infections. A vaccine can be administeredby either of the
route, orally (through mouth) or through needle injections or by aerosol [1].
Vaccine development process involves induction […]
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Role Of Vascular Endothelial Growth Factor Receptor Inhibitors In Refractory Cervical Cancer.
Download Abstract This review article focuses on the past and future aspects of
vascular endothelial growth factor inhibitors in Cervical Cancer.Vascular
endothelial growth factor (VEGF)-mediated angiogenesis is considered to play a
vital function in the tumor development and metastasis. Therefore, […]
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Immunotherapy In Metastatic Renal Cell Carcinoma.
Download Abstract Immunotherapy plays a crucial role in the treatment of patients
with renal cell carcinoma. Metastatic renal cell carcinoma (MRCC) remains a
therapeutic challenge because of its strong resistance to both chemotherapy and
radiation therapy. This review explains the […]
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Anti-Inflammatory Agents And Their Role In Atherosclerosis.
Download Abstract Atherosclerosis is a chronic disease, with the process of
narrowing and hardening of arteries and accumulation of plaques. Normally,
atherosclerosis is related with other cardiovascular disease such as peripheral
vascular disease, heart attack, and stroke. An inflammation plays […]
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Complementary Medicines And Cancer.
Download Abstract A great strength of patients use complementary medicine, which
is an adjuvant to the conventional treatment because complementary medicine is
an integrative approach. Conventional treatments have some harmful effects for
patients, but many patients use complementary medicine, along […]
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Mechanisms of Resistance to Rituximab in B-cell Lymphoma.
Rituximab or Anti-CD20, is a chimeric monoclonal antibody (MoAb)that has become a
ubiquitous component for improved therapeutic options for patients with B-cell
non-Hodgkin lymphoma (B-NHL)and other known hematological malignancies. The
MoAbs has the direct antiproliferative effect on the B cells in vitro. […]
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A Review Article On Emerging Role Of Hybrid Molecules In Treatment Of Breast Cancer.
Abstract Download Breast cancer is the most common cancer in women; however, many
of them relapse following primary treatment. The pattern of treating breast
cancer has been changed over last decades. Dendritic Cell/tumour hybrid,
hydroxyphenyltyrosinamide- chlorambucil, SNIPER, hybrid radiopharmaceutical and
[…]
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Abstract Download The article discuss about the role of peptide vaccine in Cancer
therapy. A peptide vaccine is a type of vaccine in which a peptide of the
original pathogen is used to immunize an organism. Key words:Vaccines,
Angiogenesis, […]
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Growth Factor As A Supportive Treatment In Chemotherapy.
Abstract Download Even after a lot of advancements have been made in the
treatment patterns of the various malignancies, there are still a number of
dose-limiting toxicities associated with chemotherapy. Most of these toxicities
are of hematological nature. Hence, there […]
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Principles Of Nutritional Support In Cancer Patients
Download Abstract Cancer patients are already compromised on nutrition. A good
nutrition plays a very important role in cancer patient. Malnutrition delays
overall recovery of patient from cancer treatment and may lead to further
serious complications. On the other hand, […]
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A Review Article On Neuropathic Pain.
Abstract Download Neuropathic pain is a pathological pain caused due to damaged
nerves, as a result of an injury on the somatosensory system. Its effect is
mainly on the outside of the brain and spinal cord. Therefore, it is mainly
[…]
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Download Abstract Cancer is one of the highly prevalent diseases worldwide that
affects different organs of the body, leading to the rapid and uncontrolled
division of cells, forming a mass of tumor cells. There are several conventional
therapies available for […]
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Abstract Download Different neurological disorders, including alterations of
peripheral nerves, multiple sclerosis (MS), optic neuritis (ON), acute
transverse myelitis (ATM) and posterior reversible encephalopathy syndrome
(PRES) can be associated with some types of immunotherapy. Likewise, anti-tumor
necrosis factor alpha (TNF-?) […]
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COX-2 Inhibitors And Their Role In Cancer Prevention And Treatment.
Abstract: Download The various steps in the process of carcinogenesis take many
years, which contributes to several opportunities for intervention to inhibit
growth of the disease. The reduction in the risk, associated with cancer may be
done by few effective […]
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Cancer-Related Fatigue And Its Management.
Download Abstract Fatigue is the most common symptom found in the cancer
patients, with a prevalence of more than 60%, as reported in the major part of
various studies. This paper mainly reviews the management of the cancer related
fatigue. […]
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Download Abstract Fatigue is the most common symptom found in the cancer
patients, with a prevalence of more than 60%, as reported in the major part of
various studies. This paper mainly reviews the management of the cancer related
fatigue. […]
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Role Of Immunotherapy For H. Pylori In Gastric Cancer.
Download Abstract Gastric cancer is a well-known challenging health problem in
the world, which has been deemed to be associated with Helicobacter pylori (H.
pylori). H. pylori avoid the endogenous immune reactions. An effective
production of antibody against H. pylori […]
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Immunotherapeutic Approach To Squamous Cell Carcinoma Of The Head And Neck.
Download Abstract Head and neck cancers make up of 3-5% of cancer diagnoses in
the United States. The most common occur in the squamous cells of the head and
neck. Immunotherapy is an alternative to chemotherapy and radiation therapy to
[…]
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New Targets In Treatment Of Myelodysplastic Syndrome
Download Abstract Myelodysplastic syndrome is a heterogeneous category of
hematologic disorders that has been recognized primarily by abnormal morphology
and number of blood cells originating from hematopoietic stem cells in the bone
marrow based on the genetic as well as […]
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Targeted Therapy For Chondrosarcoma.
Download Abstract Primary malignant bone tumors occur 1/100,000, of which 17-24%
consists of chondrosarcoma. Unfortunately, the cause is unknown, but there have
been several risks factors accused of causing the disease. Targeted therapy is a
cancer specific treatment alternative to […]
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Therapeutic Approach To Chordomas
Download Abstract Chordomas are neoplasms that come from the notochord's cellular
remnants. Immunotherapy is a cancer treatment alternative to chemotherapy and
radiation therapy. Its goal is to use a patient's own immune system to fight the
tumor. The immune system […]
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Novel Targets And Breast Cancer Treatment.
Download Abstract Breast cancer is the second most common cancer in women, after
skin cancer. One out of every 8 woman in the United States will develop breast
cancer. It can be caused by genetic mutations, using certain medicines, or
[…]
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Novel Approaches In Treatment Of Adult AML
Download Abstract Acute myeloid leukemia (AML) is cancer of the blood cells. This
cancer specifically affects red blood cells, platelet forming cells and other
white blood cells in the body; its incidence is very low in the United States
with […]
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Emerging Role Of Immunotherapy In Breast Cancer.
Download Abstract Breast cancer is the second most common cancer in women, after
skin cancer. One out of every 8 woman in the United States will develop breast
cancer. It can be caused by genetic mutations, using certain medicines, or
[…]
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Immunotherapeutic Approach To Osteosarcoma.
Download Abstract Osteosarcoma is a rare form of cancer that account for less
than 0.2% of all cancers diagnosed in the United States. Unfortunately, the
cause is unknown, but there have been several risks factors accused of causing
the disease […]
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Immunotherapeutic Approach To Anal Cancer.
Download Abstract Anal cancer is a rare disease that accounts for 0.4% of all
cancer diagnoses in the United States. Its incidence has increased by 2.2%
annually. The risk factors associated with anal cancer are Human Papilloma Virus
(HPV), Human […]
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Therapeutic approach to CML in TKI era.
Download Abstract Chronic myeloid leukemia is a cancer that affects the cells of
the bone marrow. These effected cells can grow and divide rapidly and spill into
other parts of the body. It is relatively prevalent in the United States
[…]
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Immunotherapy and Cervical Cancer.
Download Abstract Cervical cancer is a leading cause of death worldwide, as per
statistical analysis, it is the seventh most common cancer. Majority of the
cervical cancers are caused by persistent infections with specific types of the
human papillomavirus (HPV) […]
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HIV AND HTLV1 ASSOCIATED LYMPHOMA & IMMUNOTHERAPY.
People with HIV infections are at increased risk for lymphoma. It is a disease in
which malignant cells form in the lymphatic system of patients who have acquired
immunodeficiency syndrome. The use of highly active anti-retroviral therapy
[…]
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Immunotherapy and colon cancer.
Colon cancer is the third most commonly diagnosed cancer and the second leading
cause of cancer death in both men and women in the U.S. The exact cause of the
colonic cancer is still unknown but has several risk factors like the age
[…]
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Immunotherapy in Hodgkin Lymphoma.
Hodgkin's lymphoma is a lymphocyte cancer, with a 9,190 new cases per year in the
U.S. It is sub-divided into two main categories: the Classical Hodgkin Lymphoma
"CHL" and the Nodular lymphocyte predominant Hodgkin lymphoma "NLPHL". […]
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Role of Immunotherapy in Post Transplantation Lymphoproliferative Disorders.
Post transplantation Lymphoproliferative Disorder is the most severe complication
of both solid organ transplantation and hematopoietic stem cell transplantation.
It arises in 1-15% of transplanted patients and involves malignant and
uncontrolled […]
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Immunotherapy and polycythemia vera.
Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by
abnormal growth of erythroid precursors in the bone marrow. Almost all patients
with PV, around 97%, have a mutation in Janus kinase 2 (JAK2). It is through the
[…]
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Immunotherapeutic Approach to Laryngeal Cancer.
Laryngeal cancer is a rare cancer, accounts for 12,630 new cases in 2014 out of a
total number of 1,665,540 new cancer cases in the United States. It is mostly
Squamous in origin as the rest of head and neck tumors. Immunotherapy is an
alternative […]
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Immunotherapeutic Approach to Oropharyngeal Cancer.
Oropharyngeal cancer accounts for more than 13000 new cases in the US, which is
more common in older men, and male:female ratio is 2.7:1. Immunotherapy is an
alternative to chemotherapy and radiation therapy to treat cancer. It is
utilized to […]
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Immunotherapeutic approach to nasopharyngeal cancer.
Nasopharyngeal cancer (NPC) is a rare cancer in most populations like the
Caucasians in North America; it is a leading form of cancer in a few
well-defined populations, including natives of southern China, Southeast Asia,
the Arctic, and the Middle […]
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Application of molecular targeted therapy for refractory metastatic thyroid cancers
Thyroid cancer is one of the leading causes of death worldwide. There have been
several risks factors linked with thyroid cancer such as genetics, exposure to
radiation, body weight and insulin resistance. Poorly differentiated and
recurrent […]
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Immunotherapy and target therapy in non-Hodgkin's lymphoma.
Non-Hodgkins's lymphomas (NHL) are a heterogenous group of B and T cell
malignancies primarily involving lymphatic system. NHL is fifth leading cause of
cancer mortality. Due to evolving science and better understanding of
pathophysiology of the […]
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Immunotherapy in basal cell carcinoma.
Basal cell carcinoma (BCC), primarily affecting the photo-exposed areas of the
body, is one of the most common skin cancers accounting for about 75% of all
skin cancers. Various genetic and molecular factors, in addition to the exposure
to […]
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Immunotherapy for cancers of the biliary tract.
Cancer of the biliary tract (CBT) are relatively uncommon types of tumors. They
are frequently diagnosed at a late stage with weak response to conventional
therapies such as chemotherapy and radiotherapy. Thus a totally new and
different treatment […]
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Immunotherapy and Uterine Cancer.
Uterine cancer is the most common gynecologic malignancy diagnosed among women in
the United States. Globally, the incidence is highest in North America and
lowest in South Central Asia. Current standard therapy for uterine cancer most
commonly […]
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Immunotherapy and Acute Lymphoblastic Leukemia.
Acute lymphoblastic leukemia is a serious type of cancer that originates from the
development and differentiation o the early version of lymphocytes in the bone
marrow. With the advent of new technologies and discoveries, novel therapeutics
were […]
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Immunotherapy and myeliod metaplasia.
The past few decades have witnessed significant advances in our understanding of
the etiology, diagnosis and treatment of Myeloproliferative disorders (MPDs).
Although the causes of chronic MPDs remain unknown, Janus kinase 2 (JAK 2) gene
mutation […]
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New Targets in Treating Multiple Myeloma.
Multiple myeloma is one of the chronic lymph proliferative disorders that mainly
affect elderly population. Despite the fact that various lines of treatment have
been suggested and approved for this type of hematologic malignancy and
autologous stem […]
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Social support, quality of life and mental health status in breast cancer patients.
Objective: In this study, Objective was to assess the social support, quality of
life and mental health status in breast cancer patients. Different literatures
have highlighted the breast cancer's impact on mental health, quality of life,
financial […]
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Immunotherapy and small cell lung cancer (SCLC).
Lung cancer is the leading cause of cancer death worldwide. Lung cancers are
mainly of two types: non-small cell lung cancer (NSCLC) and small cell lung
cancer (SCLC). Small cell lung cancer accounts for about 15% of all the types of
lung cancers […]
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Immunotherapy and squamous cell carcinoma.
Squamous cell carcinoma (SCC) develops from keratinocytes. As per the statistical
analysis, it is the second most frequent skin cancer after Basal cell carcinoma
among non-melanoma skin cancers and its incidences are more than death cases .
[…]
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The histogenesis of Ewing Sarcoma.
Ewing Sarcoma is the second most frequent malignant bone tumor in adolescents and
young adults. The majority of Ewing sarcoma arises in the bone, but 15-20% of
Ewing sarcoma originates in the soft tissue surrounding bones […]
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Immunotherapy and urinary bladder cancer.
Bladder cancer is a type of cancer, which arises from the epithelial lining
(urothelium) of the urinary bladder due to the uncontrolled growth of abnormal
cells in the bladder. Transitional cell carcinoma (TCC) is the most common type
of cancer […]
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Oral Mucositis refers to oral mucosa erythematous and ulcerative lesions and is
caused by radiation dispensed in the treatment of malignant tumors of the head
and neck. Propolis shows several biological activities such as antimicrobial and
[…]
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Randomized clinical study of SCP pacliataxel in patients with advanced cervical cancer.
Introduction: Cervical cancer is the second most commonly occurring cancer in
women, and it is responsible for 15% of all female malignancies. Metastatic
cervical cancer occurs in 15-61% of cases, and available oncology therapies do
not offer the […]
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Objective: Doxorubicin has been the mainstay of treatment for advanced STS.
However, the conventional formulation of doxorubicin has not been used
clinically, due to poor penetration of the natural physiologic barriers, poor
water solubility and […]
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Introduction: Cervical cancer is the second most commonly occurring cancer in
women, and it is responsible for 15% of all female malignancies. Metastatic
cervical cancer occurs in 15-61% of cases, and available oncology therapies do
not offer the […]
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Stem Cell Therapies for Chronic Wound Management: A Comprehensive Review
Artificial: Chronic wounds, particularly prevalent among patients with
diabetes and peripheral arterial disease, pose significant health challenges
and financial burdens, with treatment costs exceeding $22 billion annually.
Conventional treatment methods, including autografts and debridement, often
involve painful procedures and limited efficacy.[…]
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Artificial intelligence (AI) is rapidly transforming healthcare, offering
promising solutions to reduce costs and improve patient outcomes. This paper
explores the diverse applications of AI in medicine, from diagnosis to drug
discovery and clinical decision support. […]
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Advances in Hair Loss Treatment and the Use of Stem Cells
Hair follicle regeneration is vital to treat those suffering from alopecia. To
accomplish this, various markers can be used to determine the causes of alopecia
and subsequent treatment methods—these range from diagnostic, prognostic, and
molecular markers to forms of histopathological examination. […]
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Ethical Dissemination of Clinical Information through Advertising and Citation of Research Papers
The dissemination of clinical information is crucial for advancing medical
knowledge and improving patient care. Ethical advertising and the citation of
clinical research papers play significant roles in this process.. […]
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A Comprehensive Diagnostic and Treatment Framework for Cervical Cancer Patients with Comorbidities
Cervical cancer is the fourth most common cancer among women
globally, accounting for approximately 604,000 new cases and
342,000 deaths annually, with the majority occurring in low- and
middle-income countries. […]
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Cognitive decline is influenced by various factors, including diet, oral and gut microbiome health, vascular function, and systemic inflammation. […]
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