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Integrative Gastroenterology and Hepatology
Immunotherapy and Pancreatic Cancer
Allen T*
, Shoja G and Court NB
Global Allied Pharmaceuticals, Center for Excellence in Research and Development, USA
Correspondence: Timothy Allen, Global Allied Pharmaceuticals, Center for Excellence in Research and
Development, 160 Vista Oak Dr. Longwood, FL 32779, USA, E-mail: timallenmed69@gmail.com
Received date: December 20, 2018; Accepted date: January 22, 2019; Published date: January 27, 2019

Abstract :Pancreatic cancer is an aggressive and highly lethal form of pancreatic malignancy which is the fourth leading cause of cancer-related deaths in men and women in the USA. According to the American Cancer Society in 2014, it was estimated that about 46,420 people (23,530 men and 22,890 women) were diagnosed of pancreatic cancer. Additionally, in the same year about 39,590 people (20,170 men and 19,420 women) died of pancreatic cancer. It is highly observed men over women and also common with increasing age. The availability of new technology in diagnosis helps in the early detection of the pancreatic cancer. These technologies will serve as the primary requirement for management of disease. The exact cause of pancreatic cancer is not known, several risk factors had been indicated leading to pancreatic cancer. Immunotherapy has been a promising development in the past few years. The recent activities have increased the understanding of the tumor microenvironment, various immunotherapeutic modalities or combination therapy (such as chemotherapy with immunotherapy) had been applied in clinical trial. Additionally, the effects of such modalities in combination with immunotherapy in cancer patients are in still exploratory phase.

Keywords: Pancreatic cancer, K-ras mutations, Cyclin-dependent kinase (CKD) Rb retinoblastoma, Protein phosphorylation, Tumorigenesis, Oncoprotein HDM2, Ductal adenocarcinoma, Pancreatic ductal cancers, Interstitial lung disease (ILD), Adoptive T cell transfer, Ligands, Kinase inhibitors, Monoclonal antibodies, Therapeutic vaccines, Adoptive T cell transfer, Adjuvant immunotherapies, Cytokines, p53 transcription factor pancreatic adenocarcinoma, Immunotherapeutic modalities

Abbreviations: CKD: Cyclin-dependent Kinase; DNA: Deoxyribose Nucleic Acid; FDA: Federal Drug Administration; ILD: Interstitial Lung Disease; MABs: Monoclonal Antibodies