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Malignant melanoma

Abstract Download Worldwide incidence of malignant melanoma has been constantly increasing during the last years. Surgical excision is effective when primary tumors are thin with thickness of less than 1milli meter and there is no evidence of metastases. At later […]

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Gastrointestinal Events Associated with Ipilimumab and combination therapies

Download Gastrointestinal Events Associated with Ipilimumab, Pazopanib, Anti PD1- Antibody and Their Management: Single and Combination Therapies Timothy Allen, MD, Ph.D1*, Giridhar M.N.V, MD,MBA1*, Ghazaleh Shoja E Razavi MD2 1Global Allied Pharmaceutical, Center for Excellence in Research & Development, USA. […]

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Abstract Download Proteasomes are multi-subunit protein complexes, which present numerous targets for therapeutic interference. The most commonly used proteasome is 26S proteasome, which contains one 20S proteolytic core subunit and two 19S regulatory cap subunits. There are three different types […]

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58. Toxicities Associated with Antibody Drug Conjugates

Abstract Download Conventional chemotherapeutic agents, in the treatment of several cancers, lack specificity, resulting in toxicities to normal tissues and poor therapeutic index. Antibody-based immunoconjugates are specifically targeted monoclonal antibodies that deliver the cytotoxic agent to the target cell. When […]

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57.Mechanisms of drug resistance in Glioblastoma Multiforme.

Abstract Download Glioblastoma multiforme (GBM) is a group of low-grade as well as high-grade brain tumors that originate from the glia;neuroglial cells and are the most common and crucial brain tumor, specially in adults. The main causes are deemed to […]

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56. A Review on Clinicopathological Correlation between Classical Inflammatory Bowel Disease and Immunotherapy Related Inflammatory Bowel Disease.

Abstract Download Blockade of various immune targets such as cytotoxic T-lymphocyte antigen-4 and Programmed cell death leads to immune-mediated tumor regression and immune-related adverse events, predominantly gastrointestinal events including diarrhea and colitis. The current review is done to understand the […]

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55. A review of newer technologies in development of nanomedicines for cancers.

Abstract Download Cancer is the leading cause of morbidity and mortality worldwide. Advances in nanotechnology have contributed to the development of nanoparticles used for medical applications and optimized therapy. Due to unique features of nanoparticles, like a large surface area, […]

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54. Safety and Efficacy of Peptide Based Vaccines.

Download Abstract A vaccine is a biological preparation which produces immunity from diseases or infections. A vaccine can be administeredby either of the route, orally (through mouth) or through needle injections or by aerosol [1]. Vaccine development process involves induction […]

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53. Role of Vascular Endothelial Growth Factor Receptor Inhibitors in Refractory Cervical Cancer.

Download Abstract This review article focuses on the past and future aspects of vascular endothelial growth factor inhibitors in Cervical Cancer.Vascular endothelial growth factor (VEGF)-mediated angiogenesis is considered to play a vital function in the tumor development and metastasis. Therefore, […]

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52. Immunotherapy in Metastatic Renal Cell Carcinoma.

Download Abstract Immunotherapy plays a crucial role in the treatment of patients with renal cell carcinoma. Metastatic renal cell carcinoma (MRCC) remains a therapeutic challenge because of its strong resistance to both chemotherapy and radiation therapy. This review explains the […]

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