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  • Stopping Pollution is the Best Solution

    "We won't have a society if
    we destroy the environment"

  • Be a Gapsos Supporter

    Lightening up the life

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  • Be a Gapsos Supporter

    Lightening up the life

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  • Be a Gapsos Supporter

    Lightening up the life

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Reasons to Help Us1

59.PROTEASOME INHIBITION IN LYMPHOPROLIFERATIVE DISORDER.

Abstract Download Proteasomes are multi-subunit protein complexes, which present numerous targets for therapeutic interference. The most commonly used proteasome is 26S proteasome, which contains one 20S proteolytic core subunit and two 19S regulatory cap subunits. There are three different types […]

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58. Toxicities Associated with Antibody Drug Conjugates

Abstract Download Conventional chemotherapeutic agents, in the treatment of several cancers, lack specificity, resulting in toxicities to normal tissues and poor therapeutic index. Antibody-based immunoconjugates are specifically targeted monoclonal antibodies that deliver the cytotoxic agent to the target cell. When […]

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57.Mechanisms of drug resistance in Glioblastoma Multiforme.

Abstract Download Glioblastoma multiforme (GBM) is a group of low-grade as well as high-grade brain tumors that originate from the glia;neuroglial cells and are the most common and crucial brain tumor, specially in adults. The main causes are deemed to […]

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56. A Review on Clinicopathological Correlation between Classical Inflammatory Bowel Disease and Immunotherapy Related Inflammatory Bowel Disease.

Abstract Download Blockade of various immune targets such as cytotoxic T-lymphocyte antigen-4 and Programmed cell death leads to immune-mediated tumor regression and immune-related adverse events, predominantly gastrointestinal events including diarrhea and colitis. The current review is done to understand the […]

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55. A review of newer technologies in development of nanomedicines for cancers.

Abstract Download Cancer is the leading cause of morbidity and mortality worldwide. Advances in nanotechnology have contributed to the development of nanoparticles used for medical applications and optimized therapy. Due to unique features of nanoparticles, like a large surface area, […]

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54. Safety and Efficacy of Peptide Based Vaccines.

Download Abstract A vaccine is a biological preparation which produces immunity from diseases or infections. A vaccine can be administeredby either of the route, orally (through mouth) or through needle injections or by aerosol [1]. Vaccine development process involves induction […]

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53. Role of Vascular Endothelial Growth Factor Receptor Inhibitors in Refractory Cervical Cancer.

Download Abstract This review article focuses on the past and future aspects of vascular endothelial growth factor inhibitors in Cervical Cancer.Vascular endothelial growth factor (VEGF)-mediated angiogenesis is considered to play a vital function in the tumor development and metastasis. Therefore, […]

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52. Immunotherapy in Metastatic Renal Cell Carcinoma.

Download Abstract Immunotherapy plays a crucial role in the treatment of patients with renal cell carcinoma. Metastatic renal cell carcinoma (MRCC) remains a therapeutic challenge because of its strong resistance to both chemotherapy and radiation therapy. This review explains the […]

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51. Anti-inflammatory agents and their role in atherosclerosis.

Download Abstract Atherosclerosis is a chronic disease, with the process of narrowing and hardening of arteries and accumulation of plaques. Normally, atherosclerosis is related with other cardiovascular disease such as peripheral vascular disease, heart attack, and stroke. An inflammation plays […]

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50. Complementary medicines and cancer.

Download Abstract A great strength of patients use complementary medicine, which is an adjuvant to the conventional treatment because complementary medicine is an integrative approach. Conventional treatments have some harmful effects for patients, but many patients use complementary medicine, along […]

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49. Complementary medicines and cancer.

Abstract Download A great strength of patients use complementary medicine, which is an adjuvant to the conventional treatment because complementary medicine is an integrative approach. Conventional treatments have some harmful effects for patients, but many patients use complementary medicine, along […]

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48. A Review Article on Emerging Role of Hybrid Molecules in Treatment of Breast Cancer.

Abstract Download Breast cancer is the most common cancer in women; however, many of them relapse following primary treatment. The pattern of treating breast cancer has been changed over last decades. Dendritic Cell/tumour hybrid, hydroxyphenyltyrosinamide- chlorambucil, SNIPER, hybrid radiopharmaceutical and […]

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47. A Review on Role of Peptide Vaccines in Cancer Therapy Treatment of Cancer Disease by Peptide Vaccine.

Abstract Download The article discuss about the role of peptide vaccine in Cancer therapy. A peptide vaccine is a type of vaccine in which a peptide of the original pathogen is used to immunize an organism.   Key words:Vaccines, Angiogenesis, […]

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46. Growth Factor As A Supportive Treatment In Chemotherapy.

Abstract Download Even after a lot of advancements have been made in the treatment patterns of the various malignancies, there are still a number of dose-limiting toxicities associated with chemotherapy. Most of these toxicities are of hematological nature. Hence, there […]

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45. Principles of nutritional support in cancer patients

Download Abstract Cancer patients are already compromised on nutrition. A good nutrition plays a very important role in cancer patient. Malnutrition delays overall recovery of patient from cancer treatment and may lead to further serious complications. On the other hand, […]

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44. A review article on Neuropathic pain.

Abstract Download Neuropathic pain is a pathological pain caused due to damaged nerves, as a result of an injury on the somatosensory system. Its effect is mainly on the outside of the brain and spinal cord. Therefore, it is mainly […]

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43. A Review article on clinical trials on hybrid drugs and nanohybrid technologies in drug development that combat cancer. Share

Download Abstract Cancer is one of the highly prevalent diseases worldwide that affects different organs of the body, leading to the rapid and uncontrolled division of cells, forming a mass of tumor cells. There are several conventional therapies available for […]

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42. Management of neurological adverse events associated with immunotherapy and a possible algorithm for clinical management.

Abstract Download Different neurological disorders, including alterations of peripheral nerves, multiple sclerosis (MS), optic neuritis (ON), acute transverse myelitis (ATM) and posterior reversible encephalopathy syndrome (PRES) can be associated with some types of immunotherapy. Likewise, anti-tumor necrosis factor alpha (TNF-?) […]

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41. COX-2 inhibitors and their role in cancer prevention and treatment.

Abstract: Download The various steps in the process of carcinogenesis take many years, which contributes to several opportunities for intervention to inhibit growth of the disease. The reduction in the risk, associated with cancer may be done by few effective […]

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40. Cancer-related fatigue and its management.

Download Abstract Fatigue is the most common symptom found in the cancer patients, with a prevalence of more than 60%, as reported in the major part of various studies. This paper mainly reviews the management of the cancer related fatigue. […]

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39. Cancer-related fatigue and its management.

Download Abstract Fatigue is the most common symptom found in the cancer patients, with a prevalence of more than 60%, as reported in the major part of various studies. This paper mainly reviews the management of the cancer related fatigue. […]

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38. Role of immunotherapy for H. pylori in gastric cancer.

Download Abstract Gastric cancer is a well-known challenging health problem in the world, which has been deemed to be associated with Helicobacter pylori (H. pylori). H. pylori avoid the endogenous immune reactions. An effective production of antibody against H. pylori […]

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37. Immunotherapeutic Approach to Squamous Cell Carcinoma of the Head and Neck.

Download Abstract Head and neck cancers make up of 3-5% of cancer diagnoses in the United States. The most common occur in the squamous cells of the head and neck. Immunotherapy is an alternative to chemotherapy and radiation therapy to […]

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36. New targets in treatment of myelodysplastic syndrome

Download Abstract Myelodysplastic syndrome is a heterogeneous category of hematologic disorders that has been recognized primarily by abnormal morphology and number of blood cells originating from hematopoietic stem cells in the bone marrow based on the genetic as well as […]

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35. Targeted therapy for Chondrosarcoma.

Download Abstract Primary malignant bone tumors occur 1/100,000, of which 17-24% consists of chondrosarcoma. Unfortunately, the cause is unknown, but there have been several risks factors accused of causing the disease. Targeted therapy is a cancer specific treatment alternative to […]

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34. Therapeutic approach to Chordomas

Download Abstract Chordomas are neoplasms that come from the notochord’s cellular remnants. Immunotherapy is a cancer treatment alternative to chemotherapy and radiation therapy. Its goal is to use a patient’s own immune system to fight the tumor. The immune system […]

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33. Novel targets and breast cancer treatment.

Download Abstract Breast cancer is the second most common cancer in women, after skin cancer. One out of every 8 woman in the United States will develop breast cancer. It can be caused by genetic mutations, using certain medicines, or […]

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32. Novel approaches in treatment of adult AML

Download Abstract Acute myeloid leukemia (AML) is cancer of the blood cells. This cancer specifically affects red blood cells, platelet forming cells and other white blood cells in the body; its incidence is very low in the United States with […]

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31. Emerging role of immunotherapy in breast cancer.

Download Abstract Breast cancer is the second most common cancer in women, after skin cancer. One out of every 8 woman in the United States will develop breast cancer. It can be caused by genetic mutations, using certain medicines, or […]

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30. Immunotherapeutic approach to Osteosarcoma.

Download Abstract Osteosarcoma is a rare form of cancer that account for less than 0.2% of all cancers diagnosed in the United States. Unfortunately, the cause is unknown, but there have been several risks factors accused of causing the disease […]

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29. Immunotherapeutic approach to Anal Cancer.

Download Abstract Anal cancer is a rare disease that accounts for 0.4% of all cancer diagnoses in the United States. Its incidence has increased by 2.2% annually. The risk factors associated with anal cancer are Human Papilloma Virus (HPV), Human […]

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28. Therapeutic approach to CML in TKI era

Download Abstract Chronic myeloid leukemia is a cancer that affects the cells of the bone marrow. These effected cells can grow and divide rapidly and spill into other parts of the body. It is relatively prevalent in the United States […]

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27. Immunotherapy and Cervical Cancer

Download Abstract Cervical cancer is a leading cause of death worldwide, as per statistical analysis, it is the seventh most common cancer. Majority of the cervical cancers are caused by persistent infections with specific types of the human papillomavirus (HPV). […]

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26. HIV AND HTLV1 ASSOCIATED LYMPHOMA & IMMUNOTHERAPY

Download Abstract People with HIV infections are at increased risk for lymphoma. It is a disease in which malignant cells form in the lymphatic system of patients who have acquired immunodeficiency syndrome. The use of highly active anti-retroviral therapy (HAART) […]

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25. Immunotherapy and colon cancer

Download Abstract Colon cancer is the third most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the U.S. The exact cause of the colonic cancer is still unknown but has several […]

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24. Immunotherapy in Hodgkin Lymphoma.

Download Abstract Hodgkin’s lymphoma is a lymphocyte cancer, with a 9,190 new cases per year in the U.S. It is sub-divided into two main categories: the Classical Hodgkin Lymphoma “CHL” and the Nodular lymphocyte predominant Hodgkin lymphoma “NLPHL”. The main […]

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23. Role of Immunotherapy in Post Transplantation Lymphoproliferative Disorders

Download Abstract Post transplantation Lymphoproliferative Disorder is the most severe complication of both solid organ transplantation and hematopoietic stem cell transplantation. It arises in 1-15% of transplanted patients and involves malignant and uncontrolled B cell proliferation. It is due to […]

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22. Immunotherapy and polycythemia vera

Download Abstract Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by abnormal growth of erythroid precursors in the bone marrow. Almost all patients with PV, around 97%, have a mutation in Janus kinase 2 (JAK2). It is through the […]

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21. Immunotherapeutic Approach to Laryngeal Cancer

Download Abstract Laryngeal cancer is a rare cancer, accounts for 12,630 new cases in 2014 out of a total number of 1,665,540 new cancer cases in the United States. It is mostly Squamous in origin as the rest of head […]

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20. Immunotherapeutic Approach to Oropharyngeal Cancer

Download Abstract Oropharyngeal cancer accounts for more than 13000 new cases in the US, which is more common in older men, and male:female ratio is 2.7:1. Immunotherapy is an alternative to chemotherapy and radiation therapy to treat cancer. It is […]

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19. Immunotherapeutic approach to nasopharyngeal cancer

Download Abstract Nasopharyngeal cancer (NPC) is a rare cancer in most populations like the Caucasians in North America; it is a leading form of cancer in a few well-defined populations, including natives of southern China, Southeast Asia, the Arctic, and […]

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18. Application of molecular targeted therapy for refractory metastatic thyroid cancers

Download Abstract Thyroid cancer is one of the leading causes of death worldwide. There have been several risks factors linked with thyroid cancer such as genetics, exposure to radiation, body weight and insulin resistance. Poorly differentiated and recurrent metastatic thyroid […]

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17. Immunotherapy and target therapy in non-Hodgkin’s lymphoma

Download Abstract Non-Hodgkins’s lymphomas (NHL) are a heterogenous group of B and T cell malignancies primarily involving lymphatic system. NHL is fifth leading cause of cancer mortality. Due to evolving science and better understanding of pathophysiology of the disease leading […]

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16.Immunotherapy in basal cell carcinoma

Download Abstract Basal cell carcinoma (BCC), primarily affecting the photo-exposed areas of the body, is one of the most common skin cancers accounting for about 75% of all skin cancers. Various genetic and molecular factors, in addition to the exposure […]

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15. Immunotherapy for cancers of the biliary tract

Download Abstract Cancer of the biliary tract (CBT) are relatively uncommon types of tumors. They are frequently diagnosed at a late stage with weak response to conventional therapies such as chemotherapy and radiotherapy. Thus a totally new and different treatment […]

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14. Immunotherapy and Uterine Cancer

Download Abstract Uterine cancer is the most common gynecologic malignancy diagnosed among women in the United States. Globally, the incidence is highest in North America and lowest in South Central Asia. Current standard therapy for uterine cancer most commonly involves […]

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12. Immunotherapy and Acute Lymphoblastic Leukemia

Download Abstract Acute lymphoblastic leukemia is a serious type of cancer that originates from the development and differentiation o the early version of lymphocytes in the bone marrow. With the advent of new technologies and discoveries, novel therapeutics were developed […]

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11. Immunotherapy and myeliod metaplasia

Download Abstract The past few decades have witnessed significant advances in our understanding of the etiology, diagnosis and treatment of Myeloproliferative disorders (MPDs). Although the causes of chronic MPDs remain unknown, Janus kinase 2 (JAK 2) gene mutation is found […]

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10. New Targets in Treating Multiple Myeloma

Download Abstract Multiple myeloma is one of the chronic lymph proliferative disorders that mainly affect elderly population. Despite the fact that various lines of treatment have been suggested and approved for this type of hematologic malignancy and autologous stem cell […]

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9. Social support, quality of life and mental health status in breast cancer patients

Download Abstract Objective: In this study, Objective was to assess the social support, quality of life and mental health status in breast cancer patients. Different literatures have highlighted the breast cancer’s impact on mental health, quality of life, financial status etc., […]

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8. Immunotherapy and small cell lung cancer (SCLC)

Download Abstract Lung cancer is the leading cause of cancer death worldwide. Lung cancers are mainly of two types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Small cell lung cancer accounts for about 15% of all […]

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7. Immunotherapy and squamous cell carcinoma

Download Abstract Squamous cell carcinoma (SCC) develops from keratinocytes. As per the statistical analysis, it is the second most frequent skin cancer after Basal cell carcinoma among non-melanoma skin cancers and its incidences are more than death cases . Australia […]

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6. The histogenesis of Ewing Sarcoma

Download Abstract Ewing Sarcoma is the second most frequent malignant bone tumor in adolescents and young adults. The majority of Ewing sarcoma arises in the bone, but 15-20% of Ewing sarcoma originates in the soft tissue surrounding bones Key words: Dung-Fang […]

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5. Immunotherapy and urinary bladder cancer

Download Abstract Bladder cancer is a type of cancer, which arises from the epithelial lining (urothelium) of the urinary bladder due to the uncontrolled growth of abnormal cells in the bladder. Transitional cell carcinoma (TCC) is the most common type […]

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4.Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Download Abstract Oral Mucositis refers to oral mucosa erythematous and ulcerative lesions and is caused by radiation dispensed in the treatment of malignant tumors of the head and neck. Propolis shows several biological activities such as antimicrobial and anti-inflammatory properties. […]

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3.Randomized clinical study of SCP pacliataxel in patients with advanced cervical cancer

Download Abstract Introduction: Cervical cancer is the second most commonly occurring cancer in women, and it is responsible for 15% of all female malignancies. Metastatic cervical cancer occurs in 15-61% of cases, and available oncology therapies do not offer the prospect […]

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1. Efficacy and safety of Specific Conjugate Particle (SCP)- Doxorubicin in Patients with Soft Tissue Sarcoma, a Randomized Clinical Study(10-April-2017)

Download Abstract Objective: Doxorubicin has been the mainstay of treatment for advanced STS. However, the conventional formulation of doxorubicin has not been used clinically, due to poor penetration of the natural physiologic barriers, poor water solubility and high side effects profile. […]

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2. Efficacy and safety of Specific Conjugate Particle (SCP)- Doxorubicinin Patients with Recurrent High-Grade Gliomas, a Randomized Clinical Study(08-June-2017)

Download Keywords Glioma; Glioblastoma; SCP-Doxorubicin; PEGDoxorubicin; Phase III trial; Conjugate particle; Adverse events; Efficacy Abstract: Objective: Doxorubicin has proven to be partly efficacious in treating glioblastoma multiforme. However, the conventional formulation of doxorubicin has not been used clinically, due to poor penetration […]

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